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REsolutions
REsolutions 02.11.2026

Colosal® – a new approach for a healthy gut microbiome

Dr. Elena Curakova

In recent years, gut health has become one of the most widely discussed topics in medicine. The reason is that we now know the intestines are responsible for much more than simply digesting food. They are home to billions of microorganisms, collectively known as the gut microbiome, which have a profound impact on overall health.

These beneficial bacteria are involved in breaking down and utilizing nutrients, producing certain vitamins, maintaining a healthy intestinal barrier and supporting the proper functioning of the immune system. In fact, more than 70% of the body’s immune cells are found in the digestive tract, further highlighting the importance of maintaining a balanced gut microbiota.

Unfortunately, modern lifestyles often disrupt this natural balance. Poor diet, fast food, stress, insufficient fiber intake, frequent use of antibiotics and other medications can lead to a decrease in the number of beneficial bacteria. When this balance is disrupted, various complaints can occur, such as bloating, gas, diarrhea, constipation, a feeling of heaviness in the stomach or discomfort after meals.

Why isn’t it enough to just take a probiotic today?

When someone mentions gut health, the first thing that comes to mind is probiotics. And indeed, they play a very important role because they introduce beneficial bacteria into the body.

However, science today shows that for a good effect, it is not enough to simply ingest beneficial bacteria.

Imagine planting a flower. Simply planting them is not enough. They also need good soil, water and suitable conditions to grow. The same principle applies to probiotics.

This is precisely why prebiotics are becoming increasingly important alongside probiotics. They serve as food for beneficial bacteria, helping them establish themselves, multiply and remain in the intestines for longer.

In recent years, scientific research has focused on postbiotics, the latest generation of ingredients to support the intestinal microbiome. These are beneficial bioactive substances that probiotic bacteria produce during their natural activity. They directly contribute to maintaining a healthy intestinal mucosa, strengthen the natural protective barrier of the intestine and help in the normal functioning of local immunity.

In other words:

  • Probiotics introduce good bacteria.
  • Prebiotics provide nourishment for these bacteria.
  • Postbiotics supply the beneficial substances that they create and through which they exert their positive effect.

That is why many experts today believe that the best approach is a combination of all three components.

What makes Colosal® different?

Colosal® does not only contain probiotics.

It is a new generation synbiotic that combines prebiotics, probiotics and postbiotics in one formulation. This approach allows for the simultaneous introduction of beneficial bacteria, their nutrition and the provision of their beneficial metabolites, thus creating optimal support for the digestive system.

This means that Colosal® not only introduces beneficial bacteria, but also provides them with the conditions for their successful development and additionally introduces their beneficial metabolites that contribute to the normal functioning of the digestive system.

It is this combination that represents its greatest advantage.

While most products on the market contain only probiotics or a combination of probiotics and prebiotics, Colosal® is the only product on the Macedonian market that combines prebiotic, probiotic, and postbiotic in a single formulation.

It therefore offers a much more comprehensive approach to maintaining the balance of the intestinal microflora.

The effectiveness of Colosal is attributed to the combination of three components:

Fructooligosaccharides (FOS) – prebiotics

Fructooligosaccharides are complex carbohydrates or natural sugars that are almost indigestible in the human body. Their role as a prebiotic is to provide nourishment for the diverse bacterial population that makes up the human intestinal flora.

Bifidobacteria – probiotics

Bifidobacteria are live bacterial cultures and important components of the intestinal microflora and are one of the most important “good” bacteria in the colon in adults and children.

Butyric acid – postbiotics

Butyric acid is a naturally occurring physiological compound in humans, formed in the large intestine as a result of the fermentation of dietary fiber.

Butyric acid is the main source of energy for colon cells (colonocytes), stimulates metabolism and their physiological maturation, and plays an important role in maintaining the integrity of the intestinal mucosa. Its presence in the intestine reduces the pH value of the intestine, thereby creating an unfavorable environment for the development of pathogenic bacteria.

When is Colosal® used?

Colosal® is intended for individuals who want to maintain or restore the balance of their intestinal microbiome and contribute to the normal functioning of the digestive system. It can be particularly recommended for:

  • in cases of disturbed intestinal microflora (dysbiosis);
  • in individuals with irritable bowel syndrome (IBS);
  • in cases of frequent bloating, gas, feeling of heaviness and discomfort in the stomach;
  • in cases with diarrhea or irregular stools;
  • for individuals with lactose or gluten intolerance, as additional support for the intestinal microbiome;
  • for patients with acute infectious diarrhea;
  • for the prevention and treatment of antibiotic-associated diarrhea and for the restoration of intestinal microbiota after antibiotic treatment
  • Clostridioides difficile infection in at-risk patients
  • after travel or sudden changes in diet;
  • during periods of increased stress, when the balance of intestinal microflora is often disrupted;

Of course, gut health does not depend solely on supplementation. A varied diet rich in fruits, vegetables, and fiber, adequate fluid intake, physical activity, and the rational use of antibiotics remain the foundation for maintaining a healthy digestive system.

With its modern formula that combines prebiotics, probiotics and postbiotics, Colosal® is a new generation product for supporting the intestinal microbiome. Thanks to this comprehensive approach, it contributes to establishing and maintaining the natural balance in the digestive system and provides complete care for intestinal health.